Dna damage response and repair genes in advanced bone and soft tissue sarcomas: an 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination

HIGHLIGHTS

  • who: Alessandra Merlini from the Papa XXIII Hospital, Italy Mie University Hospital, Japan have published the research work: DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination, in the Journal: (JOURNAL)
  • what: In this perspective, the authors focused on the combination of trabectedin, an isoquinoline alkylating agent of marine origin, and the inhibitor of the enzyme poly-(ADP-ribose) polymerase 1 (PARP1) olaparib. The aim of the present translational, exploratory study, was to look for . . .

     

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