Dna damage stress-induced translocation of mutant fus proteins into cytosolic granules and screening for translocation inhibitors

HIGHLIGHTS

• who: ufeffMasahiroufeff ufeffNogamiufeff and colleagues from the University of Modena and Reggio Emilia, Italy have published the paper: DNA damage stress-induced translocation of mutant FUS proteins into cytosolic granules and screening for translocation inhibitors, in the Journal: (JOURNAL)
• how: In the iBRN analysis a method that classifies the molecules with a substantial impact on transcriptomic data in FUSH517D mutant cells the authors identified PRKDC TIMELESS miR125b etc. using cellular models of familial FUS-ALS (Nogami et_al 2021a). These results indicated that the Venus-FUSP525L protein had a lower ability about 30% to undergo phosphorylation . . .
  

   

  

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