Dna damage to bone marrow stromal cells by anti-leukemia drugs induces chemo-resistance in acute myeloid leukemia via paracrine fgf10-fgfr2 signaling

HIGHLIGHTS

  • who: Shuang Yu from the Department of Hematology, Qilu Hospital, Shandong University, Jinan, China have published the paper: DNA damage to bone marrow stromal cells by anti-leukemia drugs induces chemo-resistance in acute myeloid leukemia via paracrine FGF10-FGFR2 signaling, in the Journal: (JOURNAL)
  • what: The authors first examined whether anti-leukemia drugs exposure increased the expression of IL-6, IL-8 and CYR61 in damaged HS-5 cells. In a HS-5 CM culture and direct co-culture model, the authors show an increase in AML cells survival and a reduction in cells . . .

     

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