Dna methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

HIGHLIGHTS

• who: Rajbir Nath Batra from the Centre University of, Cambridge, UK have published the article: DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 22/03/2021
• what: Model, the authors demonstrate methylation in hundreds of promoters and 2 thousands of distal elements to be correlated with gene_expression specifically in cis, highlighting the important role of the global methylation trends in providing the basis for numerous transcriptional aberrations, including the classical BRCA1 hypermethylation effect. The authors show that while . . .
  

   

  

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