Dna methyltransferase 1 (dnmt1) shapes neuronal activity of human ipsc-derived glutamatergic cortical neurons

HIGHLIGHTS

• who: Sarah Bachmann et al. from the Institute of Human Genetics, Faculty of Medicine and University Hospital Cologne, University of Cologne, University of Cologne, Cologne, Germany have published the paper: DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons, in the Journal: (JOURNAL)
• what: DNMT1 Depletion Reduces Spontaneous Neuronal Activity in Human iPSC-Derived Cortical Excitatory Neurons After validation of knockdown efficiency of DNMT1 siRNA in HEK cells, the authors aimed to reduce DNMT1 levels in the neuronal cultures to assess the impact of DNA methylation mediated by DNMT1 on . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.