Dna methyltransferase 1 knockdown reverses pten and vdr by mediating demethylation of promoter and protects against renal injuries in hepatitis b virus-associated glomerulonephritis

HIGHLIGHTS

  • who: Haochen Guan from the Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Haining Road, Shanghai, People`s Republic of China have published the article: DNA methyltransferase 1 knockdown reverses PTEN and VDR by mediating demethylation of promoter and protects against renal injuries in hepatitis B virus-associated glomerulonephritis, in the Journal: (JOURNAL)
  • what: Luciferase reporter assay revealed VDR as a direct target of the Snail family transcriptional repressor 1 (SNAI1) in HBx-overexpressing podocytes. inhibitor 5-azacytidine alleviated urinary and renal inflammation in HBV transgenic mice via PTEN-PI3K . . .

     

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