HIGHLIGHTS
- who: Agnieszka Smolinska et al. from the Department of Medicine A, University Medicine Greifswald, Greifswald, Germany have published the article: DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis, in the Journal: (JOURNAL)
- what: Subsequently the authors focused on estimating the impact of alt-EJ inactivation by polymerase theta (Polu03b8) deletion on pancreatic cancer development and survival in genetically engineered mouse models (GEMMs) and cancer patients. The authors show that even though Polu03b8 deficiency does not fully prevent the development of pancreatic cancer it significantly delays the onset of PanIN formation . . .
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