Dna promoter hypermethylation of melanocyte lineage genes determines melanoma

HIGHLIGHTS

• who: Phenotype and collaborators from the DivisionLund University NIH, Bethesda, Maryland, USA have published the paper: DNA Promoter Hypermethylation of Melanocyte Lineage Genes Determines Melanoma, in the Journal: (JOURNAL)
• what: The authors have explored how the melanocyte differentiation specific transcription factors, MITF and SOX10, are epigenetically regulated, determine melanoma aggressiveness, cell phenotype and therapy response. The authors further demonstrate that MITF gene_expression levels are also correlated to MITF promoter methylation status in tumors.
• how: The authors describe that loss of MITF is associated with a distinct transcriptional program MITF promoter hypermethylation and poor . . .
  

   

  

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