Dna segment capture by smc5/6 holocomplexes

HIGHLIGHTS

• who: Michael Taschner from the (UNIVERSITY) have published the Article: DNA segment capture by Smc5/6 holocomplexes, in the Journal: (JOURNAL)
• what: The authors show that plasmid molecules are topologically entrapped in the kleisin and two SMC subcompartments, but not in the full SMC compartment. The authors demonstrate that Smc5/6 holocomplexes efficiently entrap DNA molecules. Knowing that the loader intercalates between Smc5 and Smc6 heads20,21 and that the Nse4 middle part is rather short, the authors propose that steric constraints prevent Nse4 from being attached to both SMC proteins simultaneously when the loader . . .
  

   

  

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