Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with pcd and provide an excellent platform for drug screening

HIGHLIGHTS

• who: Rui Zheng from the hyperresponsiveness [10]Therefore, comprehensively investigating the function of , in ciliary development represents an excellent opportunity to understand the complex functions of ODA proteins in distal regions of motile cilia. Moreover, whether mutations in ODA genes such as , and , cause similar phenotypes and the relationship between different gene mutations and the variable clinical phenotypes of patients with PCD remain unclear. Furthermore, ODA is connected to the axoneme through a docking complex (DC), ODA-DC, including a coiledu2011coil domain containing (CCDC), CCDC151, and armadillo repeatcontaining protein , (ARMC4) [12-14]. Nexin-dynein regulatory complex contains . . .
  

   

  

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