Dnajb6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of huntington disease

HIGHLIGHTS

• who: Bhagyashree S. Joshi from the of Biomedical Engineering, University of Groningen, University Medical Center Groningen, ADeusinglaan, AV Groningen, the Netherlands have published the research work: DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease, in the Journal: (JOURNAL) of November/19,/2021
• what: The authors show that such exogenous NSC sEV-based supplementation of the chaperone DNAJB6 can reduce the iScience 24, 103282, November 19, 2021 overall levels of polyQ aggregation in_vitro and in_vivo. In this article, the use of NSC-derived sEVs containing chaperone . . .
  

   

  

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