HIGHLIGHTS
- What: This study shows that DNL343 is a brain penetrant ISR inhibitor capable of attenuating neurodegeneration in mouse models and identifies several biomarker candidates that may be used to assess treatment responses in the clinic.
- Who: Neuroscience and collaborators from the Genentech, South San Francisco, USA have published the article: DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response, in the Journal: (JOURNAL)
- How: For all animal model panels DNL343 dose is indicated on the x-axis and data is . . .
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