Docking cholesterol to integral membrane proteins with rosetta

HIGHLIGHTS

  • who: Brennica Marlow et al. from the Center for Structural Biology, Vanderbilt, Nashville, Tennessee, United States of America have published the article: Docking cholesterol to integral membrane proteins with Rosetta, in the Journal: (JOURNAL) of March/27,/2023
  • what: The approach provides a starting point for high-throughput modeling and prediction of cholesterol binding sites for further experimental validation. In the filtering step, the authors provide a specificity likelihood score. The main focus of this work is to model protein-cholesterol complexes and show that the RC protocol can be used to predict specificity likelihoods . . .

     

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