HIGHLIGHTS
- who: Naveen kadaari and collaborators from the Department SVIMS University have published the article: Docking studies to explore novel lead molecules for human spleen tyrosine kinase involved in chronic lymphocytic leukemia, in the Journal: (JOURNAL)
SUMMARY
1.B-cell chronic lymphocytic leukemia (CLL) is the most prevalent B-cell malignancy in adults. 2.Spleen tyrosine kinase (SYK) plays a pivotal role for B-lymphocyte development and maturation in B-cell receptor (BCR) signaling pathway 3.SYK is activated by conserved tyrosine residues sequential phosphorylation. SYK phosphorylates several downstream signaling elements, such as BLNK . . .
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