Does alphafold2 model proteins⠒ intracellular conformations? an experimental test using cross-linking mass spectrometry of endogenous ciliary proteins

HIGHLIGHTS

• who: Caitlyn L. McCafferty from the Center for Systems University of Texas, Austin, TX, USA have published the research: Does AlphaFold2 model proteinsu2812 intracellular conformations? An experimental test using cross-linking mass spectrometry of endogenous ciliary proteins, in the Journal: (JOURNAL) of 12/Oct/2022
• what: The authors compare intramolecular distance restraints obtained from in situ chemical cross-linking and cross-links from enriched biochemical fractions of T. thermophila ciliary proteins to the AF2-predicted structures of the 100 most cross-linked to address whether AF2 by incorporating co-evolutionary couplings38 39 would have the . . .
  

   

  

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