HIGHLIGHTS
- who: Yiouli P. Ktena and collaborators from the DepartmentNew Haven, Connecticut, USA have published the article: Donor T_cell DNMT3a regulates alloreactivity in mouse models of hematopoietic stem_cell transplantation, in the Journal: (JOURNAL)
- what: The authors demonstrate that transplantation of Dnmt3a-KO T_cells conferred significantly more rapid and severe GVHD, as well as improved GVT activity. In the work , DNMT3a appears to provide overarching regulation of T_cell alloreactivity in several established murine models of GVHD, via a multitude of pathways. The approach has uncovered multiple other potential mechanisms of allodysregulation, ongoing investigation of which is outside . . .
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