Dose-dependent regulation on prefrontal neuronal working memory by dopamine d1 agonists: evidence of receptor functional selectivity-related mechanisms

HIGHLIGHTS

SUMMARY

    Dopamine D1 receptors (D1 Rs) play important roles in the PFC (Murphy et_al, 1996a; Lidow et_al, 2003; Arnsten et_al, 2015), and D1 agonists cause marked cognitive improvement in laboratory animals (Arnsten et_al, 1994, 2017; Murphy et_al, 1996b; Cai and Arnsten, 1997; Zahrt et_al, 1997; Vijayraghavan et_al, 2007; Wang et_al, 2019; Yang et_al, 2021) and in humans (Mu et_al, 2007; Rosell et_al, 2015; Huang et_al, 2020). Alternately, neural ensembles in the PFC may be more important than single neurons (Jung et_al, 1998; Baeg et_al, 2003; Horst and Laubach, 2012; Yang et_al, 2014; Bolkan et_al, 2017 . . .

     

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