Down-regulation of mcl-1 potentiates hdaci-mediated apoptosis in leukemic cells

HIGHLIGHTS

• who: Satoshi Inoue and collaborators from the MRC Toxicology Unit, Hodgkin Building, University ofLancaster Road, Leicester, HN, UK have published the Article: Down-regulation of Mcl-1 potentiates HDACi-mediated apoptosis in leukemic cells, in the Journal: (JOURNAL)
• what: The studies provide a mechanistic basis to support the use of a combination of an HDACi either with agents that decrease Mcl-1, such as CDK inhibitors, or with TRAIL in a clinical trial in certain hematological malignancies, such as CLL.
• how: To investigate whether inhibition of class I or class II HDACs was . . .
  

   

  

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