HIGHLIGHTS
SUMMARY
Most of these CAD genetic risk variations are located in intergenic regions, at or near the promoters, indicating a possible influence on gene_expression by epigenetic regulation. Epigenetic mechanisms influence changes in gene_expression and function that might be mitotically and/or meiotically heritable and do not entail a change in DNA sequence. The main function of DNA methylation is to modulate gene_expression by modifying the accessibility of DNA to the transcriptional machinery. MicroRNAs are small noncoding RNAs (on average 18-24 nt in length) extremely conserved from an evolutionary point of view; they regulate gene_expression . . .
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