Downregulation of sirt3 aggravates lung ischemia reperfusion injury by increasing mitochondrial fission and oxidative stress through hif-1 α -dependent mechanisms

HIGHLIGHTS

• who: Chunxia Liu and colleagues from the Clinical Research Center for Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region, China have published the paper: Downregulation of SIRT3 Aggravates Lung Ischemia Reperfusion Injury by Increasing Mitochondrial Fission and Oxidative Stress through HIF-1 u03b1 -Dependent Mechanisms, in the Journal: Oxidative Medicine and Cellular Longevity 15 of 29/09/2022
• what: The authors showed that inhibition of SIRT3 aggravates LIRI in mice. In the future, the authors propose to extend the studies to elucidate how HIF-1u03b1 inhibits mitochondrial fission and its regulatory mechanisms . . .
  

   

  

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