Doxorubicin activates atm-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species*

HIGHLIGHTS

• who: Ebba U. Kurz from the ulation (53)In addition, these carriers have an intermediate sensitivity to IR (54, ). Interestingly, many of the anti-tumor chemotherapeutics used in the treatment of breast cancer have the capacity to induce DSBs or generate ROS. For breast cancer patients heterozygous for mutations in ATM, exposure to these drugs or IR could lead to more profound manifestations of side effects or the increased incidence of secondary, treatmentrelated malignancies. Identification of drugs that do not activate ATM could lead to modified treatment protocols for these patients with the aim of reducing side . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.