Doxorubicin-induced cardiotoxicity is mediated by neutrophils through release of neutrophil elastase

HIGHLIGHTS

  • who: Anchit Bhagat from the United States McMaster University, Canada have published the research work: Doxorubicin-induced cardiotoxicity is mediated by neutrophils through release of neutrophil elastase, in the Journal: (JOURNAL)
  • what: Similar to the previous report, here the authors show that the cardiac vessels from mice treated with Dox alone or Dox plus IgG appeared more punctate and collapsed, a sign of decreased pericyte coverage. The authors focused on NE as the authors have observed higher expression levels of this enzyme in hearts with Dox.
  • how: This data indicated that inhibiting or . . .

     

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