Dramatic response of metastatic cutaneous angiosarcoma to an immune checkpoint inhibitor in a patient with xeroderma pigmentosum: whole-genome sequencing aids treatment decision in end-stage disease

HIGHLIGHTS

• who: C O L D and colleagues from the (UNIVERSITY) have published the article: Dramatic response of metastatic cutaneous angiosarcoma to an immune checkpoint inhibitor in a patient with xeroderma pigmentosum: whole-genome sequencing aids treatment decision in end-stage disease, in the Journal: (JOURNAL)

SUMMARY

Upon activation, T_cells express PD-1, which interacts with PD-L1 on tumor and stromal cells, deactivating the T_cells and negatively regulating T-cell effector functions (Gentzler et_al 2016). Immune checkpoint inhibitors interfere with these checkpoints, reactivating antitumor activity of cytotoxic T_cells. Immunotherapies like anti-PD-1 . . .

 



If you want to have access to all the content you need to log in!

Thanks :)

Username or Email

Password

Remember me

Lost your password?

If you don't have an account, you can create one here.