HIGHLIGHTS
SUMMARY
Due to disadvantages, such as poor solubility, unstable, unfavorable pharmacokinetics and poor biodistribution in_vivo, lack of targeting capability, etc., traditional anticancer drugs show limited therapeutic effects with serious side effects. As the first step in the CAPIR cascade, enough circulation time of DDSs in_vivo is important, it allows the DDSs to fully accumulate in tumor tissue through the EPR effect. As a kind of hydrophilic polymer, PEG can also improve the water solubility, dispersibility, and stability of DDSs both in_vitro and in_vivo. Though "stealthy" coatings represented by PEG can prolong the circulation time of . . .
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