Drug delivery systems with a “tumor-triggered” targeting or intracellular drug release property based on depegylation

HIGHLIGHTS

• who: Zhe Ren et al. from the Hubei Key Laboratory Polymer Materials, Hubei University, Wuhan, China have published the paper: Drug Delivery Systems with a “Tumor-Triggered” Targeting or Intracellular Drug Release Property Based on DePEGylation, in the Journal: Materials 2022, 5290 of /2022/
• what: Based ondelivery. this work, shown in Figure 2, hydrophilic poly(N-isopropylacrylamide-co-N-acroyloxysuccinimide) Zhang's group proposed the concept of "tumor-triggered targeting" in 2010 .

SUMMARY

Due to disadvantages, such as poor solubility, unstable, unfavorable pharmacokinetics and poor biodistribution in_vivo, lack of targeting capability . . .

 



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