HIGHLIGHTS
SUMMARY
Medical Digital Twins are a hot topic, with a plethora of publications and opinions on what constitutes a medical digital twin (Björnsson et_al, 2020; Croatti et_al, 2020; Braun, 2021; Kamel Boulos and Zhang, 2021; Laubenbacher et_al, 2021; Masison et_al, 2021). Note that this refers to representations of biology at the cellular and molecular level and for translational/clinical purposes; this does not apply to certain biological systems than can be reliably reduced to physicsbased representations (such as material properties or fluid dynamics) or classical organ-level physiology (Bekiari et_al, 2018; Jin et_al, 2018 . . .
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