Drug-interaction between paclitaxel and goshajinkigan extract and its constituents

HIGHLIGHTS

• who: Akiko Nakayama from the (UNIVERSITY) have published the article: Drug-interaction between paclitaxel and goshajinkigan extract and its constituents, in the Journal: (JOURNAL)
• what: The authors evaluated the inhibitory or inducing effects of goshajinkigan extract (GJG) and its representative and bioavailable constituents geniposidic acid plantagoguanidinic acid paeoniflorin catalpol loganin and neoline on the metabolism of paclitaxel via CYP2C8 and CYP3A4 using pooled human liver microsomes and cultured human cryopreserved hepatocytes to provide the drug information about the pharmacokinetic interaction of this combination therapy. This study provides drug information about combination therapy with GJG product . . .
  

   

  

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