Drug resistance dependent on allostery: a p-loop rigor eg5 mutant exhibits resistance to allosteric inhibition by stlc

HIGHLIGHTS

• who: Rose-Laure Indorato et al. from the The University of Queensland, Australia have published the article: Drug resistance dependent on allostery: A P-loop rigor Eg5 mutant exhibits resistance to allosteric inhibition by STLC, in the Journal: (JOURNAL)
• what: The authors focused the attention to the Eg5 (T107N) STLC resistant and dependent cell line since the
• how: Data were analysed using GraphPad Prism 7. The enzymatic data showed that the change of an invariant threonine (T) in the nucleotide-binding GQTGTGKT motif or P-loop of Eg5 by asparagine (N) is linked . . .
  

   

  

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