Dual cyclooxygenase⠍fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site

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• who: Michael C. Goodman from the (UNIVERSITY) have published the article: Dual cyclooxygenase⠍fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site, in the Journal: (JOURNAL) of June/20,/2017
• what: The authors report the characterization of the S- and R-enantiomers of ARN2508 with regard to potency, time dependence, isoform selectivity, and substrate selectivity of COX inhibition. The authors show that each enantiomer of the compound exhibits distinct kinetics of inhibition of substrate oxygenation by both COX isoforms. The authors show that the in_vitro efficacy of ARN2508 for inhibition . . .
  

   

  

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