Dual function of usp14 deubiquitinase in cellular proteasomal activity and autophagic flux

HIGHLIGHTS

• who: Eunkyoung Kim from the National University have published the research: Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux, in the Journal: (JOURNAL) of July/17,/2018
• what: The authors report that activation of the proteasome through chemical and genetic inhibition of USP14 results in the downregulation of autophagic flux in the cell. The authors demonstrate that the UPS and autophagy have a negative-feedback connection and that USP14 is a common denominator of these two major proteolytic pathways: its inhibition upregulates cellular UPS output and downregulates autophagic flux .
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