HIGHLIGHTS
- who: Lei He from the (UNIVERSITY) have published the article: Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex, in the Journal: (JOURNAL) of 10/04/2017
- what: A series of dinuclear platinum complexes were synthesized in this study.
SUMMARY
The flexible alkyl chain would place the two Pt complexes within a distance of ±2 Å around the height of the aromatic core in c-myc GQ. Among all the GQ topology examined, highest ΔTm always occurred to c-myc GQ regardless of dinuclear Pt complexes. Pt3 showed . . .
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