Dual role for adenine nucleotides in the regulation of the atrial natriuretic peptide receptor, guanylyl cyclase-a*

HIGHLIGHTS

  • who: David C. Foster from the (UNIVERSITY) have published the Article: Dual Role for Adenine Nucleotides in the Regulation of the Atrial Natriuretic Peptide Receptor, Guanylyl Cyclase-A*, in the Journal: (JOURNAL) of June/16,/1997
  • how: Phosphatase Inhibitors and Adenine Nucleotides Potentiate Acquisition of GC-A Sensitivity-Given that phosphorylation by ATP or thiophosphorylation by ATPgS could explain the acquired sensitivity to ligand microcystin a potent Ser/Thr protein phosphatase inhibitor was tested for its ability to potentiate signaling and/or block desensitization of the ATP- or ATPgS-sensitized receptor.

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