HIGHLIGHTS
SUMMARY
The authors have studied the role of each one of H3.3A and H3.3B proteins in spermatogenesis by using conditional knock-out/knock-in (cKO/KI) epitope-tagged H3.3AHA and H3.3BHA mouse lines. In summary, the data showed that: (i) piRNA clusters were enriched of H3.3, (ii) higher is the H3.3 density, higher is the transcription of the piRNA clusters and_(iii) the depletion of the H3.3B in meiotic cells led to down-regulation of a large part of the piRNA clusters. The comparison of the gene_expression patterns . . .
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