Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity

HIGHLIGHTS

• who: Yaling Hu from the Cx3cr CreERT2, Ai, and Ai, mice were purchased from the Jackson LaboratoryHk, floxed (Hk2fl/fl) mice and Hk CreERT2-tdTomato mice were generated by Biocytogen Company (China). Hk2fl/fl mice were crossed with the Cx3cr CreERT2/+mice to generate the Cx3cr CreERT2/+::Hk2fl/fl animals. The hAPP-, mice, expressing human APP with the Swedish (p.Lys Asn andLeu) and Indiana (p.Val Phe) mutations under the control of the platelet-derived growth factor beta-chain promoter64, were from the Mutant Mouse Resource and Research Center. The glioma mice were provided by C . . .
  

   

  

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