HIGHLIGHTS
- who: Marco S. Kaiser from the , University of Basel, Basel, Switzerland have published the paper: Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis, in the Journal: (JOURNAL) of 15/06/2022
- what: The authors provide substantial evidence that hyperactive mTORC1 activates the UPS including the induction of many FoxO-regulated pro-atrophy E3 ligases through PKB/Akt suppression and ubiquitous upregulation of proteasome subunits via Nrf1 in fast but not slow-type muscles accounting for their atrophic and hypertrophic responses to mTORC1 activation respectively. Acquired reporter ion intensities in . . .
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