HIGHLIGHTS
- who: Francesca Bufalieri and collaborators from the Department of Molecular Medicine, Sapienza University, Viale Regina Elena, Rome, Italy have published the paper: DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer, in the Journal: Cancers 2020, 12, 1518 kinase serine-threonine of /2020/
- future: Although these molecules show good potency and selectivity against USP7 further in_vivo studies will be required to evaluate their therapeutic relevance in cancer treatment.
SUMMARY
In post-embryonic stages, HH signaling regulates tissue homeostasis and repair, modulating the specification of the adult stem_cells. Tumorigenesis . . .
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