Duck trim29 negatively regulates type i ifn production by targeting mavs

HIGHLIGHTS

  • who: Weiqiang Li et al. from the Institute Hydrobiology, Chinese Academy Sciences (CAS), China University Alberta, Canada have published the paper: Duck TRIM29 negatively regulates type I IFN production by targeting MAVS, in the Journal: (JOURNAL)
  • how: The results showed that duTRIM29 potently inhibited avian IFN-b and IRF7 promoter activation in a dose-dependent manner . The results indicated that duTRIM29 interacted with duMAVS but not with duRIG-I duTBK1 or duIRF7. Co-IP results showed that both the full-length and C-terminal domains (amino_acids 369571) of duTRIM29 interacted with duMAVS . Co-IP results . . .

     

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