Duplicated ribosomal protein paralogs promote alternative translation and drug resistance

HIGHLIGHTS

SUMMARY

    Indeed, despite the defect in the 60S synthesis the total amount of uL30 mRNA and protein produced in ul30bb_cells was similar or even slightly greater than that detected in ul30aa cells. This indicates that the amount of uL30 proteins is not rate limiting and that the effect observed in ul30aΔ and ul30bb_cells is not caused by decreased production of uL30 proteins in these cells. The authors sequenced ribosome-associated mRNAs, in wild-type, ul30aa and ul30bb_cells, both before and after staurosporine treatment, and ENB1 YMR1 ASG7 PRM6 96W GDB1 Analysis of the genetic and . . .

     

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