Dynamic 18f-pretomanid pet imaging in animal models of tb meningitis and human studies

HIGHLIGHTS

• who: Filipa Mota from the The overall goal of this study was to develop radiolabeled-pretomanid for dynamic, concentration-time profiles using PET to characterize pretomanid brain PK (in animal and human studies) and assess the efficacy of a pretomanid-containing regimen for TB meningitisWe performed cross-species analyses for preclinical validation of , pretomanid as a molecular imaging tool to noninvasively assess whole-body drug penetration and then optimized the radiosynthesis of , pretomanid under cGMP to facilitate the execution of first-in-human studies. Dynamic , pretomanid PET/CT was used to obtain TACs and AUCs by quantifying . . .
  

   

  

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