Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

HIGHLIGHTS

  • who: Ester Gil Vazquez from the Centre University of Oxford, Oxford, UK have published the research work: Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia, in the Journal: (JOURNAL)
  • what: The authors propose a fitness landscape model where individual tumors have equilibrated stem cell population distributions along a CBC-RSC phenotypic axis. The authors propose a conceptual phenotypic fitness landscape model to contextualize the relationship between neoplastic stem_cell activity (fitness) and cellular phenotype. As part of a fitness landscape model, the authors propose that interlinked CBC and RSC population peaks co-exist . . .

     

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