Dynamic arginine methylation of tumor necrosis factor (tnf) receptor-associated factor 6 regulates toll-like receptor signaling*

HIGHLIGHTS

• who: Irina Tikhanovich from the (UNIVERSITY) have published the research work: Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling*, in the Journal: (JOURNAL) of March/24,/2015
• what: The authors show that TRAF6-dependent TLR pathways are regulated by reversible arginine methylation of TRAF6 in a range of primary and cultured cells. If the loss of TRAF6 methylation was the primary reason for the dual effects of PRMT1 inhibition, the authors reasoned that this likely required the demethylase activity of JMJD6.
• how: Arginine Methylation . . .
  

   

  

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