Dynamic bh3 profiling identifies active bh3 mimetic combinations in non-small cell lung cancer

HIGHLIGHTS

  • who: Danielle S. Potter from the (UNIVERSITY) have published the research work: Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer, in the Journal: (JOURNAL) of 13/05/2021
  • what: The authors propose this as a rational strategy to construct combinations of targeted therapies with conventional chemotherapy agents. In Fig 1B the authors show mitochondrial priming normalized to DMSO-control, following each individual drug treatment for each of the 5 NSCLC cell lines plotted in a heat map. The aim of this experiment was to test whether DBP accurately identified . . .

     

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