Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback

HIGHLIGHTS

  • who: Joaquín Gutiérrez Mena from the (UNIVERSITY) have published the Article: Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback, in the Journal: (JOURNAL) of 20/06/2022
  • what: The authors develop a general framework for dynamic modeling of synthetic genetic circuits in the physiological context of E. coli and use a host-aware model to determine the optimal control parameters of the closed -loop compositional control system. By implementing a suitable proportional-integral-derivative (PID) controller that acts on the strain ratio, the authors demonstrate in silico closed-loop control . . .

     

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