Dynamic interactions and ca2+-binding modulate the holdase-type chaperone activity of s100b preventing tau aggregation and seeding

HIGHLIGHTS

• who: Guilherme G. Moreira from the NP-40, mM NaCl, mM Tris, pH, and a protease-inhibitor cocktail (Roche diagnostics, Basel, Switzerland have published the Article: Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: This experiment showed that S100B interacts with full-length tau in a strict Ca2+-dependent manner, and that the interaction region is large and affects both the PRR and the MTBR. The NMR data generated in this study have been deposited in the . . .
  

   

  

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