HIGHLIGHTS
SUMMARY
VEGF-A of hypoxic GBM EVs increases BBB permeability in both in_vitro and in_vivo models by reshaping the expression and organization of claudin-5 and occludin. A recent study of Shi and colleagues shed light on the content of BMEC-derived EVs represented by the abundant tetraspanin CD9, which is defined as a GSC biomarker and is able, via STAT3 activation, to significantly increase both GSC proliferation and tumor-sphere formation in_vitro and tumorigenicity in_vivo. CD9 carried by BMEC-derived EVs seems to inhibit glioma cell growth in_vitro, in contrast to the effect on . . .
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