Dynamic physiological α-synuclein s129 phosphorylation is driven by neuronal activity

HIGHLIGHTS

• who: Nagendran Ramalingam from the (UNIVERSITY) have published the Article: Dynamic physiological u03b1-synuclein S129 phosphorylation is driven by neuronal activity, in the Journal: (JOURNAL)
• what: The authors report for the first time a physiological role for pS129 in fine-tuning neuronal function: pS129 arises normally in response to synaptic activity; activity-dependent pS129 is reversible and not associated with toxicity; other known phosphorylation sites are not altered; and activity-dependent pS129 is catalyzed by Plk2 downstream of calcineurin (CaN) and counteracted by protein phosphatase 2A (PP2A). CaN, postulated to be upstream of Plk2 in . . .
  

   

  

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