Dynamics of climp-63 s-acylation control er morphology

HIGHLIGHTS

• who: Patrick A. Sandoz from the (UNIVERSITY) have published the research: Dynamics of CLIMP-63 S-acylation control ER morphology, in the Journal: (JOURNAL) of 18/02/2022
• what: Using super-resolution microscopy and focused ion beam electron microscopy, the authors show that CLIMP-63 acylation-deacylation controls the abundance and fenestration of ER sheets.
• how: The same observations were made when using ML348 and ML349 specific inhibitors of APT1 and APT2 respectively (Fig 3d Supplementary Fig 3d). The mathematical model supported by the experimental data showed that CLIMP-63 trimers rapidly undergo . . .
  

   

  

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