Dyrk1a overexpression in mice downregulates the gonadotropic axis and disturbs early stages of spermatogenesis

HIGHLIGHTS

• who: Rodolphe Dard and collaborators from the Laboratoire Processus Dégénératifs, Stress et Vieillissement, Unité de Biologie Fonctionnelle have published the research work: DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis, in the Journal: Genes 2021, 12, x FOR PEER REVIEW of /2021/
• what: Most of the studies describe azoospermia or oligospermia, elevated LH and FSH levels, normal testosterone levels, and small testes.
• how: To better ascertain DYRK1A's role in infertility in DS the authors investigated the effect of DYRK1A overexpression in transgenic mouse . . .
  

   

  

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