Dysregulated expression of transposable elements in tdp-43m337v human motor neurons that recapitulate amyotrophic lateral sclerosis in vitro

HIGHLIGHTS

• who: Braulio Valdebenito-Maturana et al. from the Instituto de Investigaciu00f3n Interdisciplinaria, Vicerrectoru00eda Acadu00e9mica, Universidad de, Campus have published the paper: Dysregulated Expression of Transposable Elements in TDP-43M337V Human Motor Neurons That Recapitulate Amyotrophic Lateral Sclerosis In Vitro, in the Journal: (JOURNAL)
• what: The authors sequenced and analyzed RNA-Seq datasets from wild-type (TDP-43WT ) and mutant (TDP-43M337V ) iMNs at 7 and 14 DIV to identify differentially expressed genes and, importantly, TEs.
• how: The authors analyzed diverse gene pathways with the disease progression in_vitro by either directly studying changes in . . .
  

   

  

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