Dysregulation of hypoxia-inducible factor 1α in the sympathetic nervous system accelerates diabetic cardiomyopathy

HIGHLIGHTS

  • who: Petra Hrabalova from the (UNIVERSITY) have published the Article: Dysregulation of hypoxia-inducible factor 1u03b1 in the sympathetic nervous system accelerates diabetic cardiomyopathy, in the Journal: (JOURNAL)
  • what: This study characterized how the combination of HIF-1u03b1 deficiency and streptozotocin (STZ)-induced diabetes affects the cardiac sympathetic nervous system and heart function of adult animals. The authors provide evidence that the combination of diabetes and the Hif1a deficient sympathetic nervous system results in compromised cardiac performance and accelerated adverse myocardial remodeling associated with the progression of diabetic cardiomyopathy. The authors focused on the early . . .

     

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